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Michele Besso (1873-1955) was Einstein's lifelong friend and his only acknowledged collaborator on the ground-breaking theory of Special Relativity (1905): as well as reflecting this close personal intimacy, Einstein's letters to Besso contain discussions of the most important scientific concepts in Einstein's work – including special and general relativity, the cosmological constant, quantum theory and unified field theory. The correspondence has been described as 'quite remarkable' and 'perhaps the most important' in Einstein's life. This second sale comprises some previously unpublished material, including letters to Besso’s family and to their close friend, the toxicologist Heinrich Zangger.